Biopolymers (flexible rods), biomembranes (fluid sheets like soap bubbles), and biomolecular bonds are the Lego blocks of cells, used repeatedly inside cells to build a variety of nanometer-sized machines that help perform functions, like allowing cells to divide, crawl, organize their interiors, sense their environment and communicate with other cells. Our group develops physics-based mathematical models of subcellular machines, with the aim of connecting nanoscale architecture to specific cellular performance objectives.

Actin asters

Simulation of formin-myosin-actin asters in the cytoplasm of cancer cells. The vertical axis is time (moving downwards).